Neurotrophic factor gene delivery supports axonal regeneration after injury

Axonal PPARγ promotes neuronal regeneration after injury.

PPARγ is a ligand-activated nuclear receptor best known for its involvement in adipogenesis and glucose homeostasis. PPARγ activity has also been associated with neuroprotection in different neurological disorders, but the mechanisms involved in PPARγ effects in the nervous system are still unknown. Here we describe a new functional role for PPARγ in neuronal responses to injury. We found both ...

Delivery of Cdc42, Rac1, and Brain-derived Neurotrophic Factor to Promote Axonal Outgrowth after Spinal Cord Injury

Integrins promote axonal regeneration after injury of the nervous system: Integrins and axonal regeneration

Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in...

Local delivery of glial cell line-derived neurotrophic factor improves facial nerve regeneration after late repair.

OBJECTIVES/HYPOTHESIS Facial nerve regeneration is limited in some clinical situations: in long grafts, by aged patients, and when the delay between nerve lesion and repair is prolonged. This deficient regeneration is due to the limited number of regenerating nerve fibers, their immaturity and the unresponsiveness of Schwann cells after a long period of denervation. This study proposes to apply...

Effects of Etanercept on axonal regeneration after peripheral nerve injury

Introduction: The peripheral nervous system is remarkable in its ability to regenerate after injury because of a local permissive environment and activation of the neuronal intrinsic growth capacity. Local induction of inflammatory cytokines, which are produced by macrophages and Schwann cells, plays a crucial role in controlling Wallerian degeneration (WD) and nerve regeneration (1). Tumor nec...